Humanin
Cytoprotection for brain, metabolism, and longevity.
SC injection — 10 mg weekly SC injection referenced in clinical protocols; dosing individualized by physician
What It Is
Humanin is a 24-amino-acid mitochondrial-derived peptide with broad cytoprotective and anti-aging properties. It was first discovered for its neuroprotective effect — rescuing neurons from Alzheimer-like insults.
Mechanism
Humanin helps preserve mitochondrial function under stress and reduces oxidative damage and inflammation. In animal models, chronic humanin treatment improved insulin sensitivity, decreased atherosclerosis, and increased lifespan and healthspan (treated mice lived longer and remained more cognitively intact). Mechanistically, humanin interacts with a cell-surface receptor (FPRL-1) and influences signaling pathways that promote cell survival (e.g. STAT3, ERK) while inhibiting apoptosis. Humanin levels naturally decline with age, especially in men.
How Dr. Emer Uses It
Clinically, it is used in cutting-edge longevity protocols to support brain health, immune function, and metabolic control. A middle-aged patient with family history of dementia might receive humanin to bolster neuronal resilience, or someone with pre-diabetes may benefit from its insulin-sensitizing effect. Dr. Emer uses humanin 10 mg weekly in the "65-Year-Old Female, Longevity & Joint Healing Archetype" case for neuroprotection and insulin sensitization.
Key Benefits
- ✓Neuroprotection — rescues neurons from Alzheimer-like insults via STAT3/ERK pathways
- ✓Reduces oxidative damage and inflammation at the mitochondrial level
- ✓Improves insulin sensitivity and decreases atherosclerosis
- ✓Increases lifespan and healthspan in animal models
- ✓Reduces autoimmune-related inflammation (reduces inflammatory signaling)
- ✓May help protect cardiovascular health (some research links higher humanin to less arterial stiffness)
Pairs Well With
Used In Programs
Safety & Considerations
Humanin is generally very well tolerated; being a natural peptide, adverse effects are minimal. Rarely, slight flushing or injection site irritation can occur. As with any potent mitoprotective agent, monitor inflammatory markers and autophagy markers (humanin can affect autophagy) to ensure it's working as intended. Older males often are prime candidates as humanin levels decline most markedly with age in men.
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All peptide therapies are prescribed under direct medical supervision.
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